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The copper binding occurs through a specific square-planar pyramid configuration involving nitrogen atoms from histidine and glycine, plus a deprotonated amide nitrogen and carboxyl oxygen from lysine

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These usually improve as the body adjusts, and medical supervision helps minimize risks

Holstein A, Plaschke A, Ptak M, Egberts EH, El-Din J, Brockmoller J et al

doi: 10.1007/s11657-022-01061-5 4 BouyerBLeroyFRudantJWeillACosteJ

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